AMPK activation flips the body’s switch from storing fat to burning fat
Author: Klaus Townsend
Adding milk to coffee may reduce its health benefits
This is due to casein in the milk binding to antioxidants in the coffee like chlorogenic acid, and making them less bioavailable.
Quick read: Sleep apnea and bleeding in the brain
In this 2025 study, moderate to severe obstructive sleep apnea had over 2x greater risk of cerebral microbleeding, which is associated with dementia and stroke.
Early access via Patreon
I’m launching my Patreon page today, and have published my next article on there. In this post I explain why that’s a good thing.
Quick read: Taurine
Taurine may affect ATP, heme, glutathione, bilirubin and more.
Podcast: Longevity as a Sport
I caught up with Adam Fiscor about the history and future of longevity as a sport, the science (and sometimes lack thereof) of biological aging clocks, open source philosophy, the athletes, my recent article, and more.
Mobility improvement
Mobility is an important and underappreciated factor for longevity. It’s becoming popular for people to know how important vo2max and strength training are to prevent risk of frailty and falls, and mobility is another part of that. In January, I increased my WODProof overall score from 74 to 81 out of 100. The app uses … Continue reading Mobility improvement
Longevity World Cup vs Rejuvenation Olympics + Biological Aging Clocks
The inaugural season of the Longevity World Cup (LWC) has officially concluded, and huge congratulations to Mike Lustgarten for taking first place overall, and Bryan Johnson for his first place in the Rejuvenation Olympics!
Let’s celebrate the athletes and answer some questions:
• What are biological age clocks, really?
• How accurate is the biological age measurement used in the LWC?
• How does LWC compare to the Rejuvenation Olympics?
• What were my results from this season?
• What can we look forward to in the 2026 season?
Research Roundup #5
In this roundup, we cover research on the benefits of cordyceps, flavonoid diversity, casein and probiotics, the risks of AI summaries, long COVID, titanium dioxide, erythritol, and the link between cardiovascular health and dementia.
2026 Protocol and biomarker updates + a challenge
Happy new year! I just added a lot of new biomarkers with a focus on physical/functional metrics like grip strength, vo2max, and mobility, and I will continue to focus on those more in the near future.